The paradox of knowledge: between ignorance and progress
21 January 2026 | 09:30 – 18:00
With his famous “I know that I know nothing,” Socrates bequeathed to Western culture an unsurpassed lesson in epistemic prudence: the awareness of the limits of one’s own knowledge.
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Such awareness is not an act of resignation, but rather an invitation to constantly transcend those very limits through research and innovation.
Throughout history, scientists, artists, and philosophers have drawn on this tension between ignorance and knowledge to achieve extraordinary goals.
The COVID-19 pandemic revealed the dual nature of this paradox: on the one hand, the power of scientific progress; on the other, the fragility of a memory that too easily forgets the lessons of the past.  In what terms, then, can we interpret this double nature of ignorance?
On the one hand, it can serve as a stimulus for innovation and improvement; on the other, it can be the cause of fatal mistakes.  We live in an era characterized by a continuous flow of information.
But how much of what we receive can we truly understand? Â The sheer quantity of data prevents us from analyzing it carefully, generating more doubts than certainties.
In this drift of knowledge, the generation of “boomers” is lost—formed with few data, much effort, and a strong critical spirit—while the “digital natives” flounder, unaccustomed to the doubts of reason.  In this scenario, Artificial Intelligence presents itself as a tool capable of processing and organizing such information, transforming it into knowledge.  Will AI succeed in bridging the gap between data and understanding—and offer us a knowledge that is more solid, coherent, and perhaps even more ethical?
PROGRAM OF THE DAY
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9:30 – Introduction and institutional greetings
Moderators:Â Luigi Ripamonti, Maira Gironi
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Knowing: Past and Future
9:40 – The tension toward knowledge: the classical world
Pietro Cappelletto
10:10 – The revolution of knowledge: Artificial Intelligence
Federico Esposti
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Historical Knowledge
10:40 – The COVID syndemic: reality and conspiracy
Massimo Filippi
11:10 – The cost of denialism
Luigi Ripamonti
11:40 – Discussion
11:50 – Break
12:10 – Memory and innovation: the immune system
Roberto Furlan
12:40 – Loss of memory and loss of identity: dementia
Federica Agosta
13:10 – Discussion
13:20 – Lunch break
Moderators:Â Giovanna Forlanelli, Antonio Catalano
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Unsolved Enigmas
14:00 – The emerging mind: how we make decisions
Gianvito Martino
14:30 – Mysteries and paradigms of archaeology
Maurizio Harari
15:00 – The mystery of consciousness
Simone Sarasso
15:30 – Can quantum mechanics reveal the human factor?
Antonio Smecca
16:00 – Community: an enigma between art and science
Francesco Valagussa
16:30 – Discussion
16:45 – Break
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Misinformation and Social Drifts
17:00 – The loneliness of the hyperconnected individual
Claudio Mencacci
17:30 – “Abolescents”: increasingly detached from reality
Anna Lucia Ogliari
18:00 – Discussion and conclusions
SPEAKERS
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Prof. Federica Agosta
Associate Professor of Neurology, Neuroimaging Unit,
Experimental Neurology Institute, Vita-Salute San Raffaele University
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Prof. Pietro Cappelletto
Classicist, PhD in Greek and Latin Philology,
Classical, Musical, and Coreutic High School “B. Zucchi”
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Dr. Antonio Catalano
Postdoctoral Research Fellow in Theoretical Philosophy,
Vita-Salute San Raffaele University
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Eng. Federico Esposti, PhD
Director of Innovation and Development,
IRCCS San Raffaele Hospital
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Prof. Massimo Filippi
Full Professor of Neurology, Vita-Salute San Raffaele University;
Head of the Neurology Department, IRCCS San Raffaele Hospital
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Dr. Giovanna Forlanelli
President, Fondazione Luigi Rovati
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Prof. Roberto Furlan
Head of the Neuroimmunology Unit;
President, International Society of Neuroimmunology
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Dr. Maira Gironi
Clinical Neurologist; PhD in Experimental Neurobiology;
Researcher in Neuroimmunology, IRCCS San Raffaele Hospital – SYNLAB Monza
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Prof. Maurizio Harari
Former Full Professor of Etruscology and Italic Archaeology
and Director of the Department of Humanities, University of Pavia;
Ordinary Member, National Institute of Etruscan and Italic Studies
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Prof. Gianvito Martino
Scientific Director, IRCCS San Raffaele Hospital;
Full Professor of Applied Biology;
Vice Rector for Research and Third Mission, Vita-Salute San Raffaele University
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Prof. Claudio Mencacci
Full Professor of Psychiatry;
Past President, Italian Society of Psychiatry;
Co-President, Italian Society of Neuropsychopharmacology
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Prof. Anna Lucia Ogliari
Associate Professor of Clinical Psychology, Vita-Salute San Raffaele University;
Head of the Child and Adolescent Clinical Psychology Unit,
IRCCS San Raffaele Turro Hospital
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Dr. Luigi Ripamonti
Senior Editor, Corriere della Sera;
Head of Corriere Salute
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Prof. Simone Sarasso
Associate Professor of Human Physiology,
University of Milan
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Dr. Antonio Smecca
Researcher, National Institute for Nuclear Physics – Rome Tre Section;
PhD in Theoretical Physics, University of Turin;
Former Researcher, Swansea University (UK)
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Prof. Francesco Valagussa
Full Professor of Aesthetics,
Vita-Salute San Raffaele University